Humanized Mice (HiMice)

HiMice are a humanized mouse model with a stably reconstituted human immune system.



Human Immune Cell Reconstitution in HiMice 


Reconstitution levels- Blood recon > 20%, Organ recon > 80%
Reconstitution levels- Blood recon > 20%, Organ recon > 80%

(Upper figure) Flow cytometry analysis of human cell lineages of HiMice. Blood samples were taken from 12 weeks old HiMice and stained with mouse CD45, human CD45 (lymphocyte common antigen), human CD56 (NK cells), human CD3 (T cells), human CD4 (Th cells), human CD8 (Tc cells), human CD19 (B cells), human CD14 (monocytes MNC) and many other cell types. (lower figure) Human organ residential Immune cells in HiMice.

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